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NBIO Presents: Dan Christoffel (University of North Carolina at Chapel Hill) "Divergent Roles of Nucleus Accumbens D1- and D2-MSNs in Regulating Hedonic Feeding"

Title: Divergent Roles of Nucleus Accumbens D1- and D2-MSNs in Regulating Hedonic Feeding   Abstract: The nucleus accumbens (NAc) is a critical node in the neural circuitry underlying reward and motivated behavior, including hedonic feeding, and its dysfunction is implicated in maladaptive behaviors in numerous psychiatric disorders. Medium spiny neurons (MSNs) in the NAc are predominantly categorized into D1 receptor-expressing (D1-MSNs) and D2 receptor-expressing (D2-MSNs) subtypes, which are thought to exert distinct and sometimes opposing roles in reward-related processes. Here, we used optogenetic, chemogenetic, and fiber photometry approaches in Cre-driver mouse lines to dissect the causal contributions of D1- and D2-MSNs to the consumption of a high-fat diet in sated animals. Activation of D1-MSNs via optogenetics or DREADDs significantly suppressed high-fat intake, whereas inhibition of these neurons increased consumption. Conversely, activation of D2-MSNs enhanced high-fat food intake, while their… Event interval: Single day event. Campus location: Magnuson Health Sciences Center G (HSG). Campus room: HSB G-328. Accessibility Contact: nbio@uw.edu. Event Types: Lectures/Seminars. Thursday, August 14, 2025, 9:30 AM – 10:30 AM.

NBIO Presents: Pavan Ramdya (École Polytechnique Fédérale de Lausanne)

Title and abstract coming soon! Event interval: Single day event. Campus location: Magnuson Health Sciences Center G (HSG). Campus room: HSB G-328. Accessibility Contact: nbio@uw.edu. Event Types: Lectures/Seminars. Tuesday, September 30, 2025, 9:30 AM – 10:30 AM.

NBIO Presents: Dorian McGavern (National Institute of Neurological Disorders and Stroke)

Event interval: Single day event. Campus location: Magnuson Health Sciences Center G (HSG). Campus room: G328. Accessibility Contact: nbio@uw.edu. Event Types: Lectures/Seminars. Thursday, October 9, 2025, 9:30 AM – 10:30 AM.

NBIO Presents: Martha Bagnall (Washington University School of Medicine)

Event interval: Single day event. Campus location: Magnuson Health Sciences Center G (HSG). Campus room: G328. Accessibility Contact: nbio@uw.edu. Event Types: Lectures/Seminars. Thursday, October 16, 2025, 9:30 AM – 10:30 AM.

NBIO Presents: Greg Field (Duke University)

Title and abstract coming soon! Event interval: Single day event. Campus location: Magnuson Health Sciences Center G (HSG). Campus room: HSB G-328. Accessibility Contact: nbio@uw.edu. Event Types: Lectures/Seminars. Thursday, October 23, 2025, 9:30 AM – 10:30 AM.

NBIO Presents: Ted Erclik (University of Toronto Mississauga)

Title and abstract coming soon! Event interval: Single day event. Accessibility Contact: nbio@uw.edu. Event Types: Lectures/Seminars. Thursday, October 30, 2025, 9:30 AM – 10:30 AM.